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Related Experiment Videos

[Physiological problems of biological evolution. "Errors" in the development of physiological functions].

K P Ivanov, N N Mel'nikova

    Uspekhi Fiziologicheskikh Nauk
    |April 7, 2005
    PubMed
    Summary

    Leukocytes (white blood cells) impede brain capillary blood flow due to their size and tendency to form clots, causing dangerous "no reflow" effects and organism death.

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    Effect of Hypothermia-Induced Respiratory Arrest on Cerebral Circulation in Rats.

    Bulletin of experimental biology and medicine·2016

    Area of Science:

    • Physiology
    • Evolutionary Biology
    • Pathology

    Context:

    • Physiological functions evolve towards complexity but can regress, leading to diseases.
    • Autoimmune diseases represent a form of evolutionary "error" or functional regression.
    • The brain's microcirculation is crucial for neurological function and survival.

    Purpose:

    • To investigate the detrimental role of leukocytes in brain microcirculation.
    • To elucidate the mechanisms by which leukocytes impair blood flow in the brain.
    • To understand the link between leukocyte behavior and the "no reflow" phenomenon.

    Summary:

    • Leukocytes, being 2-2.5 times larger than erythrocytes (red blood cells), significantly slow capillary blood flow.
    • Under hypoxic conditions, leukocytes exhibit increased adhesion, forming conglomerates that occlude brain venules and small veins.

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  • This occlusion leads to the "no reflow" effect, a critical factor in organism death.

    • Impact:

    • Highlights the pathological role of leukocytes in cerebrovascular events.
    • Provides insights into the mechanisms underlying the "no reflow" phenomenon.
    • Suggests potential therapeutic targets for mitigating leukocyte-induced brain damage.