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Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...

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Related Experiment Video

Updated: Jul 1, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
06:51

Mouse Model of Pressure Ulcers After Spinal Cord Injury

Published on: March 9, 2019

Pressure ulcers: guideline development and economic modelling.

Rosa Legood1, Elizabeth McInnes

  • 1Research Officer, Health Economics Research Centre, University of Oxford, Oxford, UK.

Journal of Advanced Nursing
|April 7, 2005
PubMed
Summary
This summary is machine-generated.

High-specification foam mattresses are cost-effective for preventing pressure ulcers. Incorporating economic evidence into clinical guidelines ensures pragmatic recommendations for patient care.

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Area of Science:

  • Healthcare Economics
  • Clinical Practice Guidelines
  • Preventive Medicine

Background:

  • Previous UK guidelines for pressure-relieving devices lacked cost-effectiveness analysis.
  • Integrating economic evidence into guidelines is a recent policy shift with limited research.

Purpose of the Study:

  • To develop clinical guidelines for pressure-relieving devices, emphasizing economic evidence.
  • To assess the clinical and cost-effectiveness of pressure-relieving devices for pressure ulcer prevention.

Main Methods:

  • Systematic literature review of clinical and cost-effectiveness data.
  • Economic modeling to evaluate comparative cost-effectiveness of devices.
  • Guideline development group review including clinicians and patient representatives.

Main Results:

  • High-specification foam mattresses significantly reduced pressure ulcer risk compared to standard mattresses.
  • Economic modeling demonstrated high-specification foam mattresses are cost-effective due to reduced treatment costs.
  • Evidence quality for other pressure-relieving devices was found to be weak.

Conclusions:

  • Cost-effectiveness assessment is crucial for developing pragmatic clinical guidelines.
  • Economic evaluation clarified evidence limitations and guided recommendations for pressure ulcer prevention.
  • High-specification foam mattresses are recommended as minimum provision for at-risk patients.