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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Erythroderma with lichenoid granulomatous features induced by erythropoietin
Ingrid H Wolf1, J Smolle, L Cerroni
1Department of Dermatology, University of Graz, Graz, Austria. ingrid.wolf@meduni-graz.at
Abstract:
The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.
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