Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Outcome studies in type 2 diabetes.

M Hanefeld1

  • 1Centre for Clinical Studies, GWT Technical University, Dresden, Germany. hanefeld@gwtonline-zks.de

Current Medical Research and Opinion
|April 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum and Plasma Levels of Vascular Endothelial Growth Factors in Relation to Quality of Glucose Control, Biomarkers of Inflammation, and Diabetic Nephropathy.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2016
Same author

Serum and Plasma Levels of Vascular Endothelial Growth Factors in Relation to Quality of Glucose Control, Biomarkers of Inflammation, and Diabetic Nephropathy.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2016
Same author

Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION).

Diabetes, obesity & metabolism·2015
Same author

Use of insulin in type 2 diabetes: what we learned from recent clinical trials on the benefits of early insulin initiation.

Diabetes & metabolism·2014
Same author

[Modern medical treatment of type 2 diabetes].

Deutsche medizinische Wochenschrift (1946)·2014
Same author

[Hypoglycemia and cardiac arrhythmia in patients with diabetes mellitus type 2].

Herz·2014

Outcome studies are crucial for measuring clinical benefits in diabetes patients. Current research reviews past findings and anticipates future insights into cardiovascular risk management for individuals with diabetes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Trials

Background:

  • Outcome studies assess clinically meaningful endpoints like mortality and cardiovascular morbidity.
  • Few trials focus exclusively on diabetes; many use surrogate endpoints with uncertain clinical translation.
  • Existing knowledge on pharmacotherapy's cardiovascular effects in diabetes comes from subgroup analyses of large trials.

Purpose of the Study:

  • To review findings from outcome studies in diabetes up to 2004.
  • To examine ongoing studies assessing cardiovascular outcomes in diabetic populations.
  • To highlight the importance of managing multiple cardiovascular risk factors in diabetes.

Main Methods:

  • Literature search of MEDLINE and EMBASE databases (1990-2005).

Related Experiment Videos

  • Review of published outcome studies concerning diabetes and cardiovascular events.
  • Analysis of ongoing trials investigating cardiovascular outcomes in diabetic patients.

    • Main Results:

    • Previous trials with lipid-modifying, antiplatelet, and antihypertensive therapies showed reduced cardiovascular risk in diabetes subgroups.
    • Landmark trials like the UK Diabetes Study and DCCT provided inconclusive data on glucose-lowering therapy's impact on cardiovascular complications.
    • Thiazolidinediones' effects on cardiovascular outcomes are being evaluated in ongoing studies.

    Conclusions:

    • Effective management of cardiovascular risk factors is essential for patients with diabetes.
    • Ongoing outcome studies, particularly those involving thiazolidinediones, are critical for understanding treatment benefits.
    • A comprehensive approach addressing multiple metabolic risk factors is vital for cardiovascular disease prevention in diabetes.