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Related Experiment Videos

[Variations on the topic of the "histone code"].

Dominique Ray-Gallet1, Annabelle Gérard, Sophie Polo

  • 1Section de Recherche, CNRS UMR 218, Institut Curie, 26, rue d'Ulm, 75248 Paris Cedex 05, France.

Medecine Sciences : M/S
|April 7, 2005
PubMed
Summary

Histone modifications and variants form a "histone code," extending genetic information to regulate epigenetic processes. These elements are crucial for establishing and maintaining epigenetic memory in eukaryotes.

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genetics

Context:

  • Histones are core structural proteins of eukaryotic chromatin.
  • Histones undergo posttranslational modifications (PTMs) like acetylation and methylation.
  • Histone variants also contribute to epigenetic regulation.

Purpose:

  • To review current knowledge on histone PTMs and their role in epigenetic regulation.
  • To describe core histone variants, their incorporation into chromatin, and their epigenetic functions.
  • To discuss the inheritance of epigenetic information mediated by histones.

Summary:

  • Histones are modified through acetylation, methylation, phosphorylation, and ubiquitination, forming a
  • Histone variants can mark specific DNA loci, influencing epigenetic memory.

Related Experiment Videos

  • The combinatorial patterns of histone modifications and variants constitute the
  • This review covers histone PTMs, histone variants, and their collective role in epigenetic information and inheritance.

    • Impact:

    • Understanding histone modifications and variants is key to deciphering epigenetic regulation.
    • This knowledge can illuminate mechanisms underlying various biological processes and diseases.
    • Provides insights into the inheritance of epigenetic traits beyond the DNA sequence.