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Updated: Aug 18, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Recent advances in molecular diagnosis and therapy of gastric cancer
Jie Chen1, Christoph Röcken, Peter Malfertheiner
1Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany.
Abstract:
Gastric cancer is the fourth most common malignancy and the second most frequent cause of cancer-related death in the world. It is often diagnosed in advanced stages when treatment options are limited, leading to a poor prognosis. During the past 15 years, much has been learnt about the molecular mechanisms of gastric carcinogenesis and the development of metastases. This coincided with the development of new techniques for functional genomics, including both transcriptomics and proteomics, which significantly improve the ability to explore new molecular alterations involved in carcinogenesis and tumor progression. An improved understanding of the molecular pathology and pathogenesis of gastric cancer may lead to a more rapid development of molecular diagnostic and patient tailored therapeutic targets.
Insights
Gastric cancer, a leading cause of cancer death, is often diagnosed late. Advances in functional genomics are revealing molecular insights crucial for developing targeted therapies and diagnostics.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Gastric cancer is a global health concern, ranking as the fourth most common malignancy and second leading cause of cancer death worldwide.
- Late-stage diagnosis limits treatment efficacy and contributes to a poor patient prognosis.
- Significant progress has been made in understanding the molecular underpinnings of gastric carcinogenesis and metastasis over the last 15 years.
Purpose of the Study:
- To explore novel molecular alterations involved in gastric cancer development and progression.
- To leverage advancements in functional genomics for a deeper understanding of gastric cancer pathogenesis.
- To identify potential molecular diagnostic and therapeutic targets for personalized gastric cancer treatment.
Main Methods:
- Utilizing advanced functional genomics techniques, including transcriptomics and proteomics.
- Analyzing molecular changes associated with carcinogenesis and tumor progression.
- Investigating molecular pathology to identify key drivers of gastric cancer.
Main Results:
- New techniques have enhanced the ability to explore molecular alterations in gastric cancer.
- Functional genomics approaches provide deeper insights into carcinogenesis and metastasis.
- Understanding molecular pathology is advancing the identification of new therapeutic targets.
Conclusions:
- Improved understanding of gastric cancer's molecular pathology and pathogenesis is critical.
- Functional genomics plays a key role in uncovering molecular targets.
- This knowledge facilitates the development of molecular diagnostics and tailored therapies for gastric cancer patients.
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