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Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning

P Veys1, K Rao, P Amrolia

  • 1Great Ormond Street Hospital (GOSH) for Children NHS Trust, London, UK. VEYSP@gosh.nhs.uk

Bone Marrow Transplantation
|April 7, 2005
PubMed

The optimal preparation for stem cell transplantation (SCT) in children with congenital immunodeficiencies is currently unknown. In all, 81 children with immunodeficiency underwent 82 SCTs using reduced-intensity conditioning (RIC). The incidence of significant GVHD was low; viral reactivation was prominent with an unexpected increase in EBV reactivation; immune reconstitution was similar between different donor groups and comparable to conventional SCT. Overall, 68/81 (84%) survive with no significant difference between donor types or between severe combined immunodeficiency (SCID) and non-SCID diseases. Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT.

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