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Updated: Aug 15, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Pneumatosis intestinalis in 9 children with an oncologic disease]
H A C Kyrieleis1, M E F Wilsterman, R S V M Severijnen
1Afd. Kindergeneeskunde, Universitair Medisch Centrum St Radboud, Postbus 910o, 6500 HB Nijmegen. h.kyrieleis@cukz.umcn.nl
Insights
Pneumatosis intestinalis (PI) in children with cancer is usually self-limiting. Supportive care is effective, and surgery is generally not needed unless an acute abdomen is present.
Area of Science:
- Pediatric Oncology
- Gastroenterology
Context:
- Pneumatosis intestinalis (PI) is a rare condition.
- Children undergoing treatment for malignant diseases are at risk.
- Understanding PI in this population is crucial for appropriate management.
Purpose:
- To investigate the characteristics of pneumatosis intestinalis (PI) in pediatric oncology patients.
- To gather data on symptomatology, diagnostics, treatment, and prognosis of PI in this cohort.
Summary:
- A retrospective review of 9 children diagnosed with PI between 1998-1999 was conducted.
- Patients had acute lymphocytic leukemia or stage IV neuroblastoma.
- Symptoms were nonspecific; PI was confined to the colon. All patients recovered with supportive care, including gastric suctioning, parenteral nutrition, and antibiotics.
Impact:
- Pneumatosis intestinalis in children with cancer is typically self-limiting with supportive care.
- Pneumoperitoneum does not necessitate surgery unless an acute abdomen is present.
- Chemotherapy can often be continued during PI management.
Objective:
To acquire knowledge regarding the rare condition pneumatosis intestinalis (PI) in children treated for malignant disease.
Design:
Retrospective.
Method:
In 1998-1999 PI was diagnosed in 9 of the 140 children with malignant disease in the department of Paediatric Oncology of the UMC St Radboud, Nijmegen, the Netherlands. By examination of the records of these 9 children, data were collected on the symptomatology, diagnostics, treatment and prognosis of PI.
Results:
The 9 children included 7 boys and 2 girls, varying in age from 2 to 12 years. In 7 patients the underlying disease was acute lymphocytic leukaemia and in 2 it was a stage IV neuroblastoma. The presenting symptoms were nonspecific and included: a distended abdomen, abdominal pain, diarrhoea and constipation. In all children, PI was located in the colon. Supplemental blood and microbiological analysis did not reveal any typical abnormalities. 8 children were treated with lactitol because of constipation. A laparotomy was performed in the first patient, while the other 8 were treated with gastric suctioning, parenteral nutrition and antibiotics. All 9 children recovered within a few weeks.
Conclusion:
With supportive care, PI in children with malignant disease is mostly a self-limiting condition. A pneumoperitoneum in PI is no indication for surgery, except in the presence of an acute abdomen. Chemotherapy can be continued.
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