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Platelet function disorder in patients with coronary slow flow

Mustafa Gökçe1, Sahin Kaplan, Yavuz Tekelioğlu

  • 1Department of Cardiology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. mustgokce@yahoo.com

Clinical Cardiology
|April 9, 2005
PubMed

Insights

Patients with coronary slow flow phenomenon (CSFP) exhibit increased platelet aggregability. This finding suggests platelet function may play a role in CSFP, a condition affecting coronary artery blood flow.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Biology

Background:

  • Coronary slow flow phenomenon (CSFP) is observed in some patients with chest pain and normal coronary arteries.
  • The exact cause of CSFP remains unclear.
  • CSFP involves delayed dye flow in epicardial coronary arteries during angiography.

Purpose of the Study:

  • To investigate potential platelet function disorders in patients diagnosed with CSFP.
  • To determine if altered platelet aggregability is associated with CSFP.

Main Methods:

  • Compared 24 patients with CSFP (using TIMI frame count) to 23 controls with normal coronary flow.
  • Measured platelet aggregability in response to ristocetin, collagen, and adenosine diphosphate (ADP).

Main Results:

  • Platelet aggregability was significantly higher in patients with CSFP compared to controls.
  • Increased aggregation was noted for ristocetin, collagen, and ADP stimuli.
  • Statistical significance was achieved with p < 0.05.

Conclusions:

  • Platelet aggregability is elevated in individuals with coronary slow flow phenomenon.
  • This suggests a potential link between platelet hyperactivity and the pathophysiology of CSFP.
Abstract

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