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Platelet function disorder in patients with coronary slow flow.
Mustafa Gökçe1, Sahin Kaplan, Yavuz Tekelioğlu
1Department of Cardiology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. mustgokce@yahoo.com
Clinical Cardiology
|April 9, 2005
Summary
Patients with coronary slow flow phenomenon (CSFP) exhibit increased platelet aggregability. This finding suggests platelet function may play a role in CSFP, a condition affecting coronary artery blood flow.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Coronary slow flow phenomenon (CSFP) is observed in some patients with chest pain and normal coronary arteries.
- The exact cause of CSFP remains unclear.
- CSFP involves delayed dye flow in epicardial coronary arteries during angiography.
Purpose of the Study:
- To investigate potential platelet function disorders in patients diagnosed with CSFP.
- To determine if altered platelet aggregability is associated with CSFP.
Main Methods:
- Compared 24 patients with CSFP (using TIMI frame count) to 23 controls with normal coronary flow.
- Measured platelet aggregability in response to ristocetin, collagen, and adenosine diphosphate (ADP).
Main Results:
- Platelet aggregability was significantly higher in patients with CSFP compared to controls.
- Increased aggregation was noted for ristocetin, collagen, and ADP stimuli.
- Statistical significance was achieved with p < 0.05.
Conclusions:
- Platelet aggregability is elevated in individuals with coronary slow flow phenomenon.
- This suggests a potential link between platelet hyperactivity and the pathophysiology of CSFP.