Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tourette's Syndrome.

Donald L Gilbert1, Tara D Lipps

  • 1Cincinnati Children’s Hospital Medical Center, Division of Neurology, ML #2015, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. d.gilbert@cchmc.org.

Current Treatment Options in Neurology
|April 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features.

EBioMedicine·2026
Same author

Multiecho Resting-State Functional Magnetic Resonance Imaging Analysis of Attention-Deficit/Hyperactivity Disorder Severity and Motor Dysfunction in a Pediatric Sample of Neurofibromatosis Type 1.

Pediatric neurology·2026
Same author

Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators.

Frontiers in psychiatry·2026
Same author

Education Research: The Future of Child Neurology Residency Training: The Perspective of a Child Neurology Society Task Force.

Neurology. Education·2026
Same author

Shortened Cortical Silent Period in Children with Attention Deficit Hyperactivity Disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Developmental delay in attaining adult levels of motor excitability in children and adolescents with Tourette syndrome: a mega-analysis study.

bioRxiv : the preprint server for biology·2026
Same journal

Visual Impairment and Driving in Older Adults: A Narrative Review.

Current treatment options in neurology·2026
Same journal

Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.

Current treatment options in neurology·2026
Same journal

Update on the Treatment of Autonomic Disorders.

Current treatment options in neurology·2025
Same journal

Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.

Current treatment options in neurology·2025
Same journal

Emerging Principles for Treating Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD).

Current treatment options in neurology·2025
Same journal

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology·2025
See all related articles

Tourette's syndrome, a neuropsychiatric disorder, requires treatment when tics cause impairment. Managing comorbid conditions like ADHD and OCD is key to effective symptom control.

Area of Science:

  • Neuropsychiatry
  • Pediatric Neurology
  • Clinical Psychology

Background:

  • Tourette's syndrome is a childhood-onset disorder featuring motor and vocal tics.
  • Frequently co-occurs with attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, and impulsivity.
  • Treatment is indicated for significant functional, social, or pain impairment, especially with self-injurious tics.

Purpose of the Study:

  • To outline treatment considerations for Tourette's syndrome.
  • To discuss management strategies for tics and comorbid conditions.
  • To review pharmacologic and non-pharmacologic interventions.

Main Methods:

  • Review of current treatment guidelines and evidence for Tourette's syndrome.
  • Discussion of pharmacologic options including alpha-2 adrenergic agonists, SSRIs, neuroleptics, and atypical antipsychotics.

Related Experiment Videos

  • Evaluation of non-pharmacologic interventions such as habit reversal treatment and deep brain stimulation.

    • Main Results:

    • Alpha-2 adrenergic agonists can reduce tics and improve ADHD symptoms.
    • ADHD treatment, including stimulants, generally does not worsen tics.
    • SSRIs may alleviate obsessive-compulsive and anxiety symptoms, indirectly reducing tics.
    • Neuroleptics and atypical antipsychotics are options for severe tics but carry risks of side effects.
    • Habit reversal treatment shows promise as a non-pharmacologic approach.
    • Deep brain stimulation is experimental but has shown benefit in severe adult cases.

    Conclusions:

    • Treatment of Tourette's syndrome should be individualized, prioritizing targets based on specific impairments and comorbid conditions.
    • A combination of pharmacologic and non-pharmacologic strategies may be necessary for optimal management.
    • Careful consideration of risks and benefits is essential when choosing interventions, particularly for severe or refractory cases.