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Characteristics of interpolyelectrolyte complexes of Eudragit E 100 with sodium alginate
R I Moustafine1, V A Kemenova, G Van den Mooter
1Department of Pharmaceutical Chemistry, State Medical University of Kazan, Kazan, Russia.
Abstract:
With a view to the application in oral drug delivery formulations, the possibility to form interpolyelectrolyte complexes (IPEC) of Eudragit E 100 (EE) with sodium alginate (AL) was investigated, employing turbidimetry, apparent viscosity measurements, FT-IR and elementary analysis. The interaction or binding ratio of a unit molecule of AL with EE was largely affected by the pH value of the media, showing a change from 1.5:1 to 1:1.25 (0.66
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