Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alginate rafts and their characterisation.

F C Hampson1, A Farndale, V Strugala

  • 1Reckitt Benckiser Healthcare (UK) Ltd., Dansom Lane, Hull HU8 7DS, UK.

International Journal of Pharmaceutics
|April 9, 2005
PubMed
Summary

Alginate antacid preparations form reflux-reducing rafts. Low acid neutralizing capacity (ANC) and calcium create the strongest, most resilient rafts for effective GERD symptom relief.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Federated Learning Survival Model and Potential Radiotherapy Decision Support Impact Assessment for Non-small Cell Lung Cancer Using Real-World Data.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia.

Orphanet journal of rare diseases·2022
Same author

A comparison of in-house and shared RapidPlan models for prostate radiation therapy planning.

Physical and engineering sciences in medicine·2022
Same author

Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [<sup>18</sup>F]FDG.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2021
Same author

Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2021
Same author

Evaluation of dual energy CT and iterative metal artefact reduction (iMAR) for artefact reduction in radiation therapy.

Australasian physical & engineering sciences in medicine·2019

Area of Science:

  • Gastroenterology
  • Pharmaceutics
  • Material Science

Background:

  • Alginate/antacid preparations aim to alleviate gastroesophageal reflux disease (GERD) symptoms.
  • These preparations function by creating a physical barrier, a floating gel or raft, atop stomach contents.
  • The raft's physical properties are crucial for its efficacy in preventing reflux.

Purpose of the Study:

  • To evaluate the in vitro effectiveness of various liquid anti-reflux products.
  • To assess raft formation, focusing on cohesion, buoyancy, volume, reflux resistance, and resilience.
  • To correlate raft properties with product formulation, including acid neutralizing capacity (ANC) and calcium content.

Main Methods:

  • Testing a range of liquid alginate/antacid products in vitro.

Related Experiment Videos

  • Assessing raft characteristics: cohesion, buoyancy, volume, resistance to reflux, and resilience.
  • Measuring acid neutralizing capacities (ANCs) of the tested products.

    • Main Results:

    • High ANC products without calcium formed weak, precipitate-like rafts.
    • High ANC products with calcium formed medium-strength rafts.
    • Low ANC products formed strong, coherent rafts; low ANC with calcium yielded the strongest rafts.
    • Stronger rafts demonstrated greater resilience and reflux resistance in an in vitro model.
    • Raft buoyancy varied significantly among coherent rafts but was unrelated to formulation or carbon dioxide.

    Conclusions:

    • Product formulation significantly impacts raft strength, cohesion, and resilience.
    • Low ANC combined with a calcium source optimizes raft properties for anti-reflux efficacy.
    • The physical characteristics of the raft are key determinants of its performance in preventing reflux.