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Updated: Aug 18, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Puberty-timing is everything!
Belinda Pinyerd1, William B Zipf
1Central Ohio Pediatric Endocrinology and Diabetes Service, Columbus, 43231, USA. bwresearch@columbus.rr.com
Abstract:
Puberty is a dynamic period of physical growth, sexual maturation, and psychosocial achievement that generally begins between age 8 and 14 years. The age of onset varies as a function of sex, ethnicity, health status, genetics, nutrition, and activity level. Puberty is initiated by hormonal changes triggered by the hypothalamus. Children with variants of normal pubertal development--both early and late puberty--are common in pediatric practice. Recognizing when variations are normal and when referral for further evaluation is indicated is an important skill.
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