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Coronary flow velocity reserve is diminished in hypertensive left ventricular hypertrophy

Attila Nemes1, Klara Neu, Tamas Forster

  • 12nd Department of Medicine and Cardiology Centre, University of Szeged, Hungary.

Kardiologia Polska
|April 9, 2005
PubMed

Insights

Coronary flow reserve (CFR) is reduced in hypertensive patients, especially those with left ventricular hypertrophy (LVH). The severity of LVH correlates with the degree of CFR reduction.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Dipyridamole stress transesophageal echocardiography (STEE) is a viable method for assessing coronary flow velocity reserve (CFR).
  • Hypertension is a significant risk factor for cardiovascular disease.

Purpose of the Study:

  • To investigate coronary flow velocity reserve (CFR) in hypertensive patients.
  • To determine the impact of left ventricular hypertrophy (LVH) on CFR in hypertension.

Main Methods:

  • Compared three groups: normotensive patients, hypertensive patients without LVH, and hypertensive patients with LVH.
  • Included 73 patients with negative coronary angiograms.
  • Utilized dipyridamole stress transesophageal echocardiography for CFR evaluation.

Main Results:

  • CFR was significantly lower in hypertensive patients with LVH compared to normotensive individuals (p<0.05).
  • Hypertensive patients without LVH showed only a slight, non-significant reduction in CFR.
  • LV mass and LV mass index were inversely correlated with CFR in hypertensive patients with LVH (r = -0.481 and -0.477, p<0.05).

Conclusions:

  • Coronary flow reserve (CFR) is diminished in patients with hypertension.
  • The extent of left ventricular hypertrophy (LVH) is directly related to the degree of CFR reduction in hypertensive patients.
Abstract

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