[Resistance to activated protein C in a patient with multiple myocardial infarctions and stroke--a case report]

Area of Science:

• Cardiology
• Hematology
• Genetics

Background:

• Recurrent cardiovascular events, including myocardial infarction (MI) and ischemic stroke, pose significant clinical challenges.
• Identifying underlying prothrombotic states is crucial for effective patient management and secondary prevention.

Observation:

• A 49-year-old female presented with a third acute MI, having a prior history of two MIs and ischemic stroke.
• Laboratory analysis revealed activated protein C resistance, a condition associated with an increased risk of blood clots.

Findings:

• Genetic testing confirmed the presence of the factor V Leiden mutation as the cause of activated protein C resistance.
• The factor V Leiden mutation is a common inherited thrombophilia that predisposes individuals to venous and arterial thrombosis.

Implications:

• This case underscores the necessity of investigating thrombophilia in patients experiencing recurrent thromboembolic events.
• Early diagnosis and appropriate anticoagulation strategies are vital for managing patients with factor V Leiden mutation and preventing further cardiovascular complications.