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Optic nerve infiltration by acute lymphoblastic leukemia: MRI contribution.

Maria de Fátima Soares1, Flávio Túlio Braga, Antônio José da Rocha

  • 1Department of Diagnostic Imaging, Paulista School of Medicine, Federal University of São Paulo, Serviço de Diagnóstico por Imagem, Santa Casa de Misericórdia de São Paulo, Rua Napoleao de Barros 800, São Paulo, 04024, Brazil.

Pediatric Radiology
|April 9, 2005
PubMed
Summary

Acute lymphoblastic leukemia (ALL) can infiltrate the optic nerve, potentially causing blindness. Early detection via MR imaging is crucial for leukemic patients with eye symptoms, even in remission.

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Area of Science:

  • Oncology
  • Ophthalmology
  • Radiology

Background:

  • Acute lymphoblastic leukemia (ALL) is a hematologic malignancy.
  • Ocular complications can arise in patients with ALL.
  • Optic nerve infiltration is a rare but serious complication of ALL.

Observation:

  • A case of ALL with optic nerve infiltration is presented.
  • Clinical presentation and Magnetic Resonance (MR) imaging features are described.
  • The patient experienced ocular complaints.

Findings:

  • MR imaging demonstrated optic nerve infiltration in the ALL patient.
  • Early detection of optic nerve involvement is critical.
  • Prompt diagnosis and therapy are necessary to prevent vision loss.

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Implications:

  • Recognizing the clinical and imaging characteristics of optic nerve infiltration in ALL is vital.
  • MR imaging should be considered for leukemic patients with ocular symptoms, including those in remission.
  • Timely intervention can prevent irreversible blindness in ALL patients with ocular complications.