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B-type natriuretic peptide in patients with clinical hyperthyroidism
1Department of Cardiology, Lishui City Central Hospital, Zhejiang Province, the People's Republic of China.
Journal of Endocrinological Investigation
|April 9, 2005
Summary
Plasma B-type natriuretic peptide (BNP) is elevated in hyperthyroidism, primarily due to left ventricular dysfunction. BNP measurement may aid in detecting heart failure in these patients.
Area of Science:
- Cardiology
- Endocrinology
- Biomarkers
Background:
- Hyperthyroidism can impact cardiovascular function.
- B-type natriuretic peptide (BNP) is a marker for cardiac stress.
Purpose of the Study:
- Investigate plasma BNP levels in hyperthyroid patients.
- Determine the clinical significance of BNP in hyperthyroidism.
Main Methods:
- Measured plasma BNP in 67 hyperthyroid patients and 32 healthy controls.
- Assessed left ventricular anatomy and function using echocardiography.
Main Results:
- Hyperthyroid patients showed significantly higher BNP levels (186+/-140 ng/l) vs. controls (34+/-17 ng/l).
- Elevated BNP was predominantly observed in patients with left ventricular dysfunction.
- BNP levels were similar to controls in hyperthyroid patients with normal left ventricular function.
Conclusions:
- Plasma BNP is significantly elevated in hyperthyroidism, linked to left ventricular dysfunction.
- BNP measurement can assist in identifying heart failure in clinical hyperthyroidism.