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Updated: May 1, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Plant sterols and their role in combined use with statins for lipid lowering
Lena Normén1, Daniel Holmes, Jiri Frohlich
1Canadian HIV Trials Network, Pacific Region, St Paul's Hospital/Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. lnormen@providencehealth.bc.ca
Abstract:
Cardiovascular disease (CVD) is currently one of the major contributors to the global burden of disease. Combination treatments to promote a maximal reduction of the ratio between total cholesterol and high-density lipoprotein are currently the most effective way of preventing CVD. In this review, we assess the role of plant sterols and statins in CVD prevention. Statins have been used by millions of patients at high to moderate risk of CVD, while plant sterols are potentially available to whole populations in food products. The benefits and risks of each compound, as well as the combination, are discussed.
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