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Updated: Aug 11, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
Expedient synthesis and design strategies for new peptoid construction
Benjamin C Gorske1, Sarah A Jewell, Emily J Guerard
1Department of Chemistry, 1101 University Avenue, University of Wisconsin, Madison, Wisconsin 53706-1322, USA.
Abstract:
[reaction: see text] A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers capable of displaying unique and stable structural motifs-microwave-assisted solid-phase synthesis will enable their future study and application.
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