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Propranolol intoxication revealing a Brugada syndrome
Philip Aouate1, Jerome Clerc, Philippe Viard
1Arrhythmias Department, Laënnec Hospital, Creil, France. Philip.aouate@ch-creil.fr
Journal of Cardiovascular Electrophysiology
|April 9, 2005
Summary
This case report details a young man who developed Brugada syndrome after a propranolol overdose. This highlights the potential dangers of beta-blockers in individuals with underlying Brugada syndrome.
Area of Science:
- Cardiology
- Clinical Toxicology
Background:
- Brugada syndrome is a genetic disorder affecting heart rhythm.
- Beta-blockers are commonly prescribed for cardiovascular conditions.
Observation:
- A 24-year-old man presented with Brugada syndrome following a significant propranolol overdose.
- Initial medical interventions and tests were largely unremarkable, except for ECG findings.
Findings:
- Electrocardiogram (ECG) revealed a typical coved-type Brugada pattern after propranolol ingestion.
- Follow-up ECG showed partial normalization, and an ajmaline test confirmed Brugada syndrome.
- Propranolol's membrane-stabilizing effects or ICaL inhibition may explain the ECG changes.
Implications:
- This is the first report linking beta-blocker intoxication to Brugada syndrome manifestation.
- Highlights potential risks of beta-blockers in undiagnosed Brugada syndrome patients.
- Underscores the importance of considering drug-induced effects on cardiac electrical activity.