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Updated: Aug 18, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Cutaneous lesions: benign and malignant
1Department of Dermatology, University of Virginia, Primary Care Center, Third Floor, Lee Street, Charlottesville, VA 22908, USA. jak7t@hotmail.com
Abstract:
This article reviews the clinical characteristics, histology, biologic behavior, and recommended treatment for several benign and malignant lesions that may arise on the head and neck. Nevus sebaceus and congenital melanocytic nevus are two benign lesions that can present at a size of several centimeters. Surgical excision may be considered for cosmetic purposes and to reduce the small risk for the development of malignancy within each lesion. Basal and squamous cell carcinoma, lentigo maligna and lentigo maligna melanoma, dermatofibrosarcoma protuberans, and Merkel cell carcinoma are malignant lesions for which surgical excision is the recommended treatment. Local flap reconstruction may be used to address the surgical defects resulting from excision of these benign and malignant conditions.
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