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Updated: Aug 18, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations
Lauren A Weiss1, Lucille A Lester, James E Gern
1Department of Human Genetics, University of Chicago, 920 East 58th Street, CSLC 507C, Chicago, IL 60637, USA.
Rationale:
Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes.
Methods And Measurements:
We genotyped and performed association tests on 19 single nucleotide polymorphisms in ITGB3 in the Hutterites, a founder population, and in three outbred replication populations.
Main Results:
Variation in ITGB3 was strongly associated with susceptibility to bronchial hyperresponsiveness and protection from allergic sensitization to mold allergens in this population. Three independent case-control populations representing Caucasians and African Americans were used to replicate this finding, also revealing ITGB3 alleles that are associated with asthma susceptibility and protection from mold allergen sensitization.
Conclusions:
This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens.
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