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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

480
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.5K
Renal Clearance01:23

Renal Clearance

2.7K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.7K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

620
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
620
Drug Elimination: Non-Renal Routes01:23

Drug Elimination: Non-Renal Routes

3.3K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
3.3K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

3.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.5K

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Related Experiment Video

Updated: Feb 7, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Renal cell carcinoma.

W Kimryn Rathmell1, Paul A Godley, Brian I Rini

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA. Rathmell@med.unc.edu

Current Opinion in Oncology
|April 9, 2005
PubMed
Summary

Recent advances in renal cell carcinoma (RCC) research highlight targeted therapies and immunotherapy. Understanding RCC biology offers new hope for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Clinical Therapeutics

Background:

  • Renal cell carcinoma (RCC) has historically seen limited therapeutic advances.
  • Understanding the underlying molecular biology of RCC is crucial for developing effective treatments.

Purpose of the Study:

  • To review recent developments in the biology and clinical therapeutics of renal cell carcinoma (RCC).
  • To emphasize the need for a deeper understanding and testing of rationally targeted agents in RCC.

Main Methods:

  • Review of current literature on renal cell carcinoma (RCC) biology and therapeutics.
  • Analysis of targeted agents and immunotherapies in clinical use and investigation.

Main Results:

  • Von Hippel-Lindau (VHL) gene inactivation is a key driver in clear cell RCC, leading to vascular endothelial growth factor (VEGF) overexpression.

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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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  • Targeted therapies against VEGF show anti-tumor activity in RCC.
  • Immunotherapy is a current standard of care and an active area of research in RCC.
  • Active surveillance of small renal masses is a potential clinical strategy.

    • Conclusions:

    • Renal cell carcinoma (RCC) serves as a model for developing targeted therapies based on biological insights.
    • Recent breakthroughs offer significant potential for improving clinical outcomes in RCC patients.