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[A new method for the determination of captopril]
W Ma1
1Department of Chemical Engineering, Huaihai Institute of Technology, 222005 Lianyungang.
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|April 12, 2005
Summary
A new photometric method accurately determines captopril levels in medicine. This simple, rapid technique utilizes the Cu(I)-neocuproine complex for reliable captopril quantification.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of captopril is crucial for therapeutic drug monitoring.
- Existing methods for captopril determination may lack simplicity or speed.
Purpose of the Study:
- To develop and validate a novel photometric method for determining captopril.
- To establish a simple, rapid, and accurate analytical procedure for captopril quantification.
Main Methods:
- A photometric method was developed utilizing the color formation of the Cu(I)-neocuproine complex.
- Captopril acted as a reducing agent for Cu(II) to form the colored Cu(I) complex.
- The absorbance of the complex was measured to quantify captopril concentration.
Main Results:
- The new method demonstrated simplicity and rapidity in captopril determination.
- Results obtained using the photometric method showed agreement with the established tungsten blue method.
- The formation of the Cu(I)-neocuproine complex served as a reliable indicator for captopril presence.
Conclusions:
- The developed photometric method offers a viable alternative for routine captopril analysis.
- This method provides a simple, rapid, and accurate approach for pharmaceutical quality control of captopril.