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[Hepatitis B virus infection in hemodialysis patients]
1First Military Medical University, Guangzhou.
Insights
Hepatitis B virus (HBV) prevalence is high in hemodialysis patients (78.4%). Blood transfusions are identified as the primary cause of HBV infection among these patients, with prevalence increasing over time.
Area of Science:
- Hepatology
- Nephrology
- Infectious Diseases
Background:
- Hepatitis B virus (HBV) poses a significant risk to patients undergoing hemodialysis.
- Understanding HBV prevalence and transmission routes is crucial for patient safety in chronic kidney disease (CKD) management.
Purpose of the Study:
- To determine the prevalence of Hepatitis B virus (HBV) infection markers in hemodialysis patients.
- To compare HBV prevalence among hemodialysis patients with other patient groups, including those with chronic kidney disease and those receiving blood transfusions.
- To identify the primary transmission route of HBV in hemodialysis patients.
Main Methods:
- A cross-sectional study involving 199 hemodialysis patients.
- Follow-up of 60 hemodialysis patients for over one year.
- Comparison of HBV marker prevalence with blood-transfused patients, non-transfused general medical patients, and chronic kidney disease patients.
Main Results:
- The prevalence of HBV markers in hemodialysis patients was 78.4%.
- Prevalence rates were 76.5% in blood-transfused patients, 60.0% in non-transfused general medical patients, and 62.2% in chronic kidney disease patients.
- HBV prevalence increased with the duration of hemodialysis in the followed-up group.
- Blood transfusion was identified as the main cause of HBV infection in hemodialysis patients.
Conclusions:
- Hemodialysis patients exhibit a high prevalence of Hepatitis B virus infection.
- Blood transfusion is the predominant factor contributing to HBV transmission in this vulnerable population.
- Implementing stricter transfusion protocols and screening may reduce HBV incidence in hemodialysis settings.
Abstract:
Hepatitis B virus infection in 199 patients undergone hemodialysis was compared with that in patients with chronic kidney diseases, patients received blood-transfusion and general medical patients. Of 199 hemodialysis patients, 60 were followed up for over one years. It was found the prevalence of HBV markers (previous and current infection) in these patients was 78.4%, that in the blood-transfused patients 76.5%, in the non-transfused general medical patients, 60.0% and in the patients with chronic kidney diseases 62.2%. The HBV prevalence in 60 followed up hemodialysis patients was increasing with the duration of hemodialysis. Analysis indicates that blood-transfusion is the main cause of HBV infection in the hemodialysis patients.