[Environmental and inheritive factors on large bowel cancer]

In order to clarify the influence of inherit and environmental factors on the large bowel cancer, a population-based case-control study involving 850 cases and 857 controls matched by age and sex, and a entailed family cancer history survey were carried out from September 1988 through August 1989. Multivariate analysis showed that less intake of crude fibre increased risk of the cancer whereas vegetables was negatively associated after controlling for some possible confounding factors. The intake of fat, protein and meat slightly raised the risk of the cancer. Univariate analysis showed that the history of large bowel cancer in first degree relatives had a remarkable risk (RR = 2.2, P less than 0.05), but adjusting environmental factors (especially dietary factors, e. g. fat, protein, crude fibre, calories ect.) the history had no close relationship with the cancer. The heritability of large bowel cancer was 16.78 +/- 6.20%.