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Related Experiment Videos

Plasticizers in denture soft-lining materials: leaching and biodegradation.

E Christian Munksgaard1

  • 1Department of Dental Materials, School of Dentistry, University of Copenhagen, Copenhagen N, Denmark. ecm@odont.ku.dk

European Journal of Oral Sciences
|April 12, 2005
PubMed
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Esterase activity in immersion media significantly increases phthalate leaching from soft lining materials. This finding suggests potential health risks, as leaching levels approach a fraction of the lowest observed adverse effect level (LOAEL).

Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Toxicology

Background:

  • Soft lining materials are used in dentures to improve comfort and fit.
  • Plasticizers, such as phthalates, are common components of these materials.
  • Phthalate leaching from medical devices is a concern due to potential health effects.

Purpose of the Study:

  • To investigate the effect of esterase activity on the leaching rate of plasticizers from soft lining materials.
  • To compare phthalate leaching in a buffer simulating saliva versus a buffer without esterase activity.

Main Methods:

  • Soft lining materials were immersed in aqueous buffers with and without esterase activity.
  • Buffers contained non-ionic detergent to mimic saliva's dissolving capacity for phthalates.

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  • Phthalate leaching was quantified over 28 days.

    • Main Results:

    • Esterase activity in the immersion medium significantly increased the rate of phthalate diffusion from the soft lining materials.
    • Average leaching rates were 4.5 mg kg(-1) d(-1) within 2 days and 1.1 mg kg(-1) d(-1) within 28 days.
    • Measured leaching levels were approximately 1/10 of the lowest observed adverse effect level (LOAEL) of 52 mg kg(-1).

    Conclusions:

    • Esterase activity, similar to that found in saliva, enhances plasticizer leaching from soft lining materials.
    • The in vivo leaching levels of phthalates may be a significant fraction of the LOAEL, warranting further investigation.
    • These findings highlight the importance of considering the oral environment's enzymatic activity in assessing the safety of denture materials.