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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Antimicrobial susceptibility patterns of Staphylococcus aureus in Poland obtained by the National Quality Assurance
B Matynia1, E Młodzinska, W Hryniewicz
1Division of Microbiology, National Institute of Public Health, Warsaw, Poland.
Abstract:
As part of the Polish external quality assurance scheme, clinical laboratories were asked to send five consecutive isolates of Staphylococcus aureus and the corresponding susceptibility results to the national Centre of Quality Control in Microbiology. Of 1376 isolates submitted as S. aureus from 276 medical centres, 13 (< 1%) had been misidentified by local laboratories. Of 181 (13.5%) methicillin-resistant S. aureus (MRSA) isolates, most were identified correctly (c. 98% of laboratories). Although all MRSA isolates were fully susceptible to vancomycin, teicoplanin and linezolid, they were usually multiresistant; almost 23% were resistant to seven antimicrobial agents. Most (> 90%) MSSA isolates were susceptible to the tested antibiotics, except penicillin (21% susceptible) and tetracycline (62.4% susceptible). In addition to evaluating the proficiency of testing by local laboratories, the study yielded valuable information regarding the susceptibility patterns of S. aureus isolates in Poland.
Insights
Clinical labs in Poland correctly identified most Staphylococcus aureus, including methicillin-resistant strains (MRSA). However, MRSA showed high multidrug resistance, while MSSA was largely susceptible except to penicillin and tetracycline.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- External quality assurance programs are crucial for monitoring laboratory performance.
- Staphylococcus aureus, including methicillin-resistant strains (MRSA), is a significant pathogen.
- Understanding antimicrobial susceptibility patterns is vital for effective treatment strategies.
Purpose of the Study:
- To assess the accuracy of Staphylococcus aureus identification by Polish clinical laboratories.
- To determine the antimicrobial susceptibility profiles of S. aureus, including MRSA and methicillin-susceptible S. aureus (MSSA) isolates.
- To evaluate the performance of laboratories within the Polish external quality assurance scheme.
Main Methods:
- Analysis of 1376 S. aureus isolates submitted from 276 medical centers as part of a national quality control program.
- Microbiological identification and antimicrobial susceptibility testing of submitted isolates.
- Evaluation of laboratory identification accuracy and resistance patterns.
Main Results:
- Less than 1% of submitted S. aureus isolates were misidentified by local laboratories.
- Approximately 98% of laboratories correctly identified methicillin-resistant S. aureus (MRSA) isolates.
- While MRSA isolates were susceptible to vancomycin, teicoplanin, and linezolid, they exhibited high multidrug resistance (23% resistant to seven agents).
- Most MSSA isolates (>90%) were susceptible to tested antibiotics, with exceptions for penicillin (21% susceptible) and tetracycline (62.4% susceptible).
Conclusions:
- Clinical laboratories in Poland demonstrate high proficiency in identifying S. aureus and MRSA.
- MRSA isolates in Poland are frequently multidrug-resistant, necessitating careful treatment selection.
- MSSA isolates show widespread susceptibility, though resistance to penicillin and tetracycline is notable.
- The study provides critical data on S. aureus susceptibility patterns in Poland.
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