Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Silencing viruses by RNA interference.

Florence Colbère-Garapin1, Bruno Blondel, Aure Saulnier

  • 1Laboratoire des Virus Entérotropes et Stratégies Antivirales, Institut Pasteur, 75724 Paris cedex 15, France. fcolbere@pasteur.fr

Microbes and Infection
|April 12, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ERGA-BGE reference genome of <i>Diadema setosum:</i> the Black Longspine Urchin invading the Mediterranean sea.

Open research Europe·2026
Same author

ERGA-BGE genome of <i>Dailognatha quadricollis,</i> an East Mediterranean darkling beetle.

Open research Europe·2026
Same author

Eukaryotic MAGs from the NEREA observatory: expanding the coastal microbiome dataset.

Scientific data·2026
Same author

The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons.

BMC biology·2026
Same author

Water mass specific genes dominate the Southern Ocean microbiome.

Nature communications·2026
Same author

Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity.

Nature·2026
Same journal

The extent of monocytic myeloid suppressor cells induction determines the host immune response during Mycobacterium avium infection.

Microbes and infection·2025
Same journal

Culture-attenuated pathogenic Leptospira lose the ability to survive complement lytic activity due to decreased C4BP uptake.

Microbes and infection·2025
Same journal

Exploring the link between genetically predicted plasma cathepsins and COVID-19: A mendelian randomization study of susceptibility and severity.

Microbes and infection·2025
Same journal

Laboratory parameters and serum tube agglutination test as markers for brucellosis treatment response.

Microbes and infection·2025
Same journal

Corrigendum to "Lactococcus lactis and Bifidobacterium longum attenuate Clostridioides difficile- or Clostridium symbiosum-induced colitis and depression/anxiety-like behavior in male mice" [Microb Infect 27(7) (2025) 105560].

Microbes and infection·2025
Same journal

Disrupted Microbiome-Metabolome networks underlie gut barrier and immune imbalance in severe fever with thrombocytopenia syndrome.

Microbes and infection·2025
See all related articles

Post-transcriptional gene silencing (PTGS) offers novel methods for studying viral cycles and host interactions. This technique is a powerful tool for viral research and developing new therapies against viral diseases.

Area of Science:

  • Virology
  • Molecular Biology
  • Gene Silencing

Background:

  • Post-transcriptional gene silencing (PTGS) provides new avenues for investigating viral replication.
  • Plus-strand RNA viruses are suitable targets for small interfering RNAs (siRNAs) due to their genomic functions.

Purpose of the Study:

  • To explore the utility of PTGS in studying viral cycles and host-pathogen interactions.
  • To highlight PTGS as an alternative to reverse genetics for various virus types.
  • To showcase PTGS applications in disease modeling and therapeutic development.

Main Methods:

  • Utilizing small interfering RNAs (siRNAs) for gene silencing.
  • Modifying cellular gene expression to study viral roles.
  • Applying PTGS for studying viral pathogenesis and host responses.

Related Experiment Videos

Main Results:

  • PTGS serves as an alternative to reverse genetics for RNA viruses.
  • PTGS enables elucidation of gene functions in viral cycles and pathogenesis.
  • PTGS facilitates the creation of animal models for human diseases.

Conclusions:

  • PTGS is a versatile tool for viral research, offering insights into viral mechanisms and host interactions.
  • PTGS presents a promising therapeutic strategy for combating viral infections and associated pathologies, including tumorigenesis.