Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do antiepileptic drugs accelerate forgetting?

Hennric Jokeit1, Günter Krämer, Alois Ebner

  • 1Swiss Epilepsy Center, Bleulerstrasse 60, 8008 Zurich, Switzerland. h.jokeit@swissepi.ch

Epilepsy & Behavior : E&B
|April 12, 2005
PubMed
Summary

High doses of certain antiepileptic drugs may impair memory retention in epilepsy patients. This study found accelerated forgetting in refractory epilepsy patients with high drug serum levels, impacting verbal and visual information retention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SRP orchestrates protein biogenesis beyond initial ER membrane targeting.

Nature communications·2026
Same author

"Epileptics as drivers"- the first report on motor vehicle accidents due to epileptic seizures in 1906.

Epilepsy & behavior : E&B·2026
Same author

Complex emotion recognition in neurological and neurodevelopmental conditions.

Acta psychologica·2026
Same author

Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed.

Nature structural & molecular biology·2026
Same author

Cotranslational Assembly of Oligomeric Proteins.

Annual review of biochemistry·2026
Same author

NAC promotes co-translational protein folding at the ribosomal tunnel exit.

Molecular cell·2026

Area of Science:

  • Neurology
  • Neuroscience
  • Pharmacology

Background:

  • Epilepsy affects one-third of patients, often requiring high-dose or polytherapy antiepileptic drugs (AEDs).
  • High AED dosages are linked to increased cognitive side effects, impacting patient quality of life.
  • Refractory epilepsy necessitates understanding drug-specific cognitive impacts.

Purpose of the Study:

  • To investigate the effects of carbamazepine, phenobarbital, and phenytoin on memory in refractory temporal lobe epilepsy.
  • To determine if AED serum levels influence the acquisition and retention of verbal and visual information.
  • To identify potential cognitive risks associated with specific AEDs in epilepsy management.

Main Methods:

  • Retrospective analysis of 162 patients with refractory temporal lobe epilepsy.

Related Experiment Videos

  • Assessment of verbal and visual information acquisition and retention.
  • Controlled for intelligence, age, epilepsy duration, and seizure frequency.

    • Main Results:

    • Patients with high serum levels of studied AEDs showed impaired retention, not acquisition, of new information.
    • No significant differences in memory functioning were observed between the specific AEDs tested.
    • Cognitive impairment was selective for information retention, independent of other patient factors.

    Conclusions:

    • High serum levels of carbamazepine, phenobarbital, and phenytoin are associated with accelerated forgetting in refractory epilepsy.
    • AED-induced memory impairment may be a significant concern for patients with difficult-to-treat epilepsy.
    • Further research is needed to mitigate cognitive side effects of AEDs in epilepsy treatment.