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Updated: Aug 18, 2026

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
Published on: March 15, 2018
Regulation of dendritic development by calcium signaling
1Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. lredmond@mail.mcg.edu
Abstract:
Neuronal activity can have profound effects on dendrite morphology in the developing brain. The effects of neuronal activity on dendritic morphology are mediated by calcium signaling. While many effects of calcium on dendrite structure occur locally at the site of calcium entry into the cytoplasmic milieu, elevation of cytoplasmic calcium is also translated into changes in gene transcription. Decoding the calcium signal into specific changes in gene transcription involve coordinating the action of a number of kinases, phosphatases, transcription factors and transcriptional coactivators. This review focuses on the contribution of calcium-dependent transcription on the control of dendritic morphology.
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