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Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
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Sumoylation silences the plasma membrane leak K+ channel K2P1

Sindhu Rajan1, Leigh D Plant, Michael L Rabin

  • 1Department of Pediatrics, Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, 5721 South Maryland Avenue, Chicago, Illinois 60637, USA.

Cell
|April 12, 2005
PubMed

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Overview
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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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