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Related Experiment Videos

Benign breast disease in systemic sclerosis (SSc). A case-control study.

R J McKendry1, M Cyr, P Dale

  • 1Rheumatic Diseases Unit, Ottawa General Hospital, University of Ottawa, Ontario, Canada.

Clinical and Experimental Rheumatology
|May 1, 1992
PubMed
Summary

Systemic Sclerosis (SSc) patients showed a higher prevalence of Benign Breast Disease (BBD) compared to Rheumatoid Arthritis (RA) patients. However, SSc and Osteoarthritis (OA) groups had similar BBD proportions, with no clear risk factors identified.

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Area of Science:

  • Rheumatology
  • Oncology
  • Women's Health

Background:

  • Systemic Sclerosis (SSc) is a connective tissue disease.
  • Benign Breast Disease (BBD) encompasses various non-cancerous breast conditions.
  • The potential association between SSc and BBD requires investigation.

Purpose of the Study:

  • To investigate the prevalence of Benign Breast Disease (BBD) in women with Systemic Sclerosis (SSc).
  • To compare BBD frequency in SSc patients against Rheumatoid Arthritis (RA) and Osteoarthritis (OA) controls.
  • To identify potential risk factors associated with BBD in SSc.

Main Methods:

  • A case-control study matching 41 SSc patients with RA and OA controls based on age, disease duration, and gender.
  • Structured telephone interviews were conducted to assess BBD prevalence and risk factors.

Related Experiment Videos

  • Statistical analysis compared BBD frequencies between the SSc, RA, and OA groups.

    • Main Results:

    • SSc patients exhibited a significantly higher prevalence of BBD compared to RA patients (12/41 vs. 4/41, p<0.04).
    • The prevalence of BBD in SSc patients was similar to that in OA controls (7/28 vs. 9/28).
    • No evaluated risk factors explained the observed differences in BBD prevalence.

    Conclusions:

    • Systemic Sclerosis may be associated with an increased prevalence of Benign Breast Disease.
    • The lower BBD prevalence in RA patients might be linked to higher NSAID use, though other factors are possible.
    • Further research with a healthy control group is needed to clarify the true prevalence of BBD in SSc and OA.