Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pain TRPs.

Haibin Wang1, Clifford J Woolf

  • 1Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Neuron
|April 12, 2005
PubMed
Summary

Transient receptor potential (TRP) ion channels act as gateways in sensory systems, converting environmental stimuli into nerve signals. Their precise regulation is vital for normal sensation and preventing pain hypersensitivity, especially after inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central sensitization: when is this the right terminology?

Pain·2026
Same author

Correction: Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion.

Disease models & mechanisms·2026
Same author

A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy.

Cell reports. Medicine·2026
Same author

Targeting G <sub>i/o</sub> -coupled GPCRs to inhibit nociceptors: insights from the serotonin receptor Htr1b and triptans.

bioRxiv : the preprint server for biology·2026
Same author

Postnatal gene restoration in succinic semialdehyde dehydrogenase deficiency (SSADHD) reveals phenotype reversibility.

bioRxiv : the preprint server for biology·2026
Same author

Colitis-induced visceral pain recruits central neurotensin neurons that modulate colonic sensitivity.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Sensory Physiology

Background:

  • Transient receptor potential (TRP) ion channels are critical molecular gateways that link environmental stimuli to the nervous system.
  • These channels transduce thermal, chemical, and mechanical signals into electrical currents, initiating sensory perception.
  • Their function is essential for thermal and pain sensations, particularly in nociceptor terminals.

Purpose of the Study:

  • To highlight the crucial role of TRP ion channels in sensory transduction.
  • To emphasize the importance of regulating TRP channel expression, localization, and function.
  • To explain the contribution of TRP channels to pain hypersensitivity following inflammation.

Main Methods:

  • Review of existing literature on TRP channel function in sensory systems.
  • Analysis of TRP channel regulation mechanisms, including translation, trafficking, and posttranslational modifications.
  • Focus on the role of TRP channels in nociceptor terminals during inflammatory conditions.

Main Results:

  • TRP channels are key interfaces between the environment and the nervous system.
  • Regulation of TRP channel activity is essential for sensory perception and pain modulation.
  • Inflammation induces changes in TRP channel expression and function, leading to pain hypersensitivity.

Conclusions:

  • Precise control over TRP ion channels is fundamental for sensory processing.
  • Dysregulation of TRP channels, particularly post-inflammation, significantly contributes to pain states.
  • Understanding TRP channel dynamics offers insights into managing pain hypersensitivity.

Related Experiment Videos