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Updated: Aug 18, 2026
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Spinal rhabdomyosarcoma in a child with lipomyelomeningocele
Wolfgang Wagner1, Dorothee Koch
1Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospitals, Mainz, Germany. wagner@nc.klinik.uni-mainz.de
Abstract:
Malignant tumors arising within dysrhaphic malformations are very rare and are mostly teratomas; so far, only one rhabdomyosarcoma has been reported in this context. We report another case of a girl with lipomyelomeningocele who developed a lumbar rhabdomyosarcoma 2 years after birth and primary closure of the neural tube defect. We present clinical, radiological and pathological findings, discuss possible mechanisms of malignant transformation and review the literature.
