Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic allograft nephropathy.

Lynn D Cornell1, Robert B Colvin

  • 1Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. lcornell@partners.org

Current Opinion in Nephrology and Hypertension
|April 12, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates.

Nature communications·2026
Same author

Tubulointerstitial diseases: an updated framework for diverse and emerging entities.

Kidney international·2026
Same author

Corrigendum to "Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: A multicenter international study" [American Journal of Transplantation 25 (2025) 1631-1642].

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Normalization of nCounter Gene Expression Data Alters Molecular Diagnostics in Kidney Transplantation.

Journal of the American Society of Nephrology : JASN·2026
Same author

A Patient With Kidney Failure, Polyclonal Hypergammaglobulinemia, and Lymphadenopathy: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
See all related articles

Chronic allograft nephropathy, a major cause of kidney transplant loss, is complex with identifiable immune and nonimmune factors. Recognizing these specific causes is key to improving patient outcomes and understanding disease progression.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Pathology

Background:

  • Chronic allograft nephropathy (CAN) is the primary reason for late kidney transplant failure.
  • CAN is a complex condition with diverse etiologies, including both immune and nonimmune factors.
  • Accurate diagnosis and categorization of CAN causes are often challenging.

Purpose of the Study:

  • To review recent advancements in understanding the heterogeneous causes of CAN.
  • To highlight methods for distinguishing specific contributors to chronic allograft dysfunction.
  • To emphasize the need for further research into CAN pathogenesis.

Main Methods:

  • Review of recent studies on CAN natural history.
  • Analysis of protocol biopsies for subclinical rejection.

Related Experiment Videos

  • Application of C4d staining to differentiate antibody-mediated rejection.
  • Evaluation of nonimmune mechanisms, including calcineurin inhibitor dosing and senescence.

    • Main Results:

    • Studies reveal the natural history of CAN and subclinical cellular rejection via protocol biopsies.
    • C4d staining aids in differentiating antibody-mediated chronic rejection from other causes.
    • Nonimmune factors, such as reduced calcineurin inhibitor levels and cellular senescence, are increasingly recognized contributors to CAN.
    • Recent research has enhanced understanding of CAN pathogenesis.

    Conclusions:

    • CAN is a multifactorial disease with identifiable immune and nonimmune components.
    • Histological features and laboratory tests can help categorize specific causes of CAN.
    • Distinguishing between various recognizable causes of chronic allograft dysfunction is crucial for advancing knowledge.
    • Further investigation is needed for CAN cases with indeterminate etiology.