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Recent advances in dendritic cell biology

Sylvia Adams1, David W O'Neill, Nina Bhardwaj

  • 1NYU Cancer Institute Tumor Vaccine Center, New York University School of Medicine, New York, New York 1006, USA. sylvia.adams@med.nvu.edu

Journal of Clinical Immunology
|April 12, 2005
PubMed

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...