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Updated: Aug 18, 2026
Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease
Published on: April 19, 2015
[Epidemic keratoconjunctivitis. Detecting adenoviruses]
J Mielke1, M Grüb, N Freudenthaler
1Abteilung 2, Sektion für Motilitätsstörungen, Universitäts-Augenklinik Tübingen. joerg.mielke@med.uni-tuebingen.de
Objective:
The validity of the 15-min adenovirus assay SAS Adenotest was evaluated compared with virus detection by polymerase chain reaction (PCR) from conjunctival swabs.
Methods:
In 75 patients with assumed epidemic keratoconjunctivitis, adenovirus detection from conjunctival swabs was performed by the immunochromatographic assay SAS Adenotest and PCR.
Results:
In 25 patients adenovirus was detected by PCR, 18 of whom were detected by the SAS Adenotest and 7 of whom were not. No false positive results occurred. Sensitivity was 72% and specificity was 100%.
Conclusions:
The results indicate that rapid adenovirus detection with the SAS Adenotest is a useful tool in early epidemic keratoconjunctivitis. An additional PCR should be performed when clinical symptoms persist for 5 days or more.
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