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Updated: Aug 17, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Nitroxyl (HNO): chemistry, biochemistry, and pharmacology
Jon M Fukuto1, Christopher H Switzer, Katrina M Miranda
1Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095-1772, USA. jfukuto@mednet.ucla.edu
Abstract:
Recent discoveries of novel and potentially important biological activity have spurred interest in the chemistry and biochemistry of nitroxyl (HNO). It has become clear that, among all the nitrogen oxides, HNO is unique in its chemistry and biology. Currently, the intimate chemical details of the biological actions of HNO are not well understood. Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology.
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