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Tylosin-responsive chronic diarrhea in dogs
Elias Westermarck1, Teresa Skrzypczak, Jaana Harmoinen
1Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland. elias.westermarck@helsinki.fi
Journal of Veterinary Internal Medicine
|April 13, 2005
Summary
Tylosin effectively treats chronic diarrhea in dogs, but it often returns after medication stops. Further research is needed to find the exact cause of this tylosin-responsive diarrhea (TRD).
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Microbiology
Background:
- Chronic diarrhea affects numerous dogs, significantly impacting their quality of life.
- Tylosin-responsive diarrhea (TRD) is a condition characterized by recurring diarrhea in dogs, often affecting large breeds.
- The exact cause of TRD remains largely unknown, necessitating further investigation.
Purpose of the Study:
- To investigate the efficacy of tylosin in treating chronic diarrhea in dogs.
- To explore potential causes and contributing factors of tylosin-responsive diarrhea (TRD).
- To evaluate the relapse rate of diarrhea after tylosin discontinuation.
Main Methods:
- A cohort of fourteen dogs with chronic diarrhea was treated with tylosin.
- Diarrhea recurrence was monitored after tylosin treatment was withdrawn.
- Other potential causes of diarrhea, including parasites and specific bacterial infections, were ruled out.
Main Results:
- Tylosin successfully resolved diarrhea in all dogs within 3 days, with most responding within 24 hours.
- Diarrhea recurred in 85.7% of dogs within 30 days of discontinuing tylosin.
- Standard treatments like prednisone and probiotics did not prevent diarrhea relapse.
Conclusions:
- Tylosin is an effective short-term treatment for chronic diarrhea in dogs.
- The underlying cause of TRD is likely an organism sensitive to tylosin but difficult to eradicate.
- Further research is required to identify the specific etiology of TRD.