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Related Experiment Videos

Position paper: Single-dose activated charcoal.

P A Chyka1, D Seger, E P Krenzelok

  • 1Tennessee Poison Center, Department of Medicine, Vanderbilt University Medical Center, VUMC Nashville, TN 37232-4632, USA.

Clinical Toxicology (Philadelphia, Pa.)
|April 13, 2005
PubMed
Summary
This summary is machine-generated.

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Single-dose activated charcoal therapy is not routinely recommended for poisoning. Its effectiveness significantly decreases over time, with questionable clinical benefit after one hour post-ingestion.

Area of Science:

  • Toxicology
  • Emergency Medicine

Background:

  • Single-dose activated charcoal (AC) therapy is used to treat poison ingestion.
  • Volunteer studies indicate AC effectiveness diminishes with time post-ingestion.

Framework:

  • AC effectiveness is time-dependent, with significant reductions in poison absorption observed at 30, 60, 120, and 180 minutes post-dosing.
  • No robust clinical studies demonstrate the benefit of single-dose AC therapy.

Implementation:

  • AC administration may be considered within one hour of ingesting a potentially toxic, charcoal-adsorbable poison.
  • Routine administration of single-dose AC is not advised due to limited evidence of clinical outcome improvement.

Implications:

  • The clinical significance of reduced poison absorption after one hour is questionable.

Related Experiment Videos

  • Contraindications include an unprotected airway; AC should not be routinely administered.
  • Current evidence does not support revising previous guidelines on single-dose AC use.