[Specialised pediatric pathology service]

Area of Science:

• Pathology
• Obstetrics & Gynecology
• Neonatology

Context:

• The Leningrad Regional Children's Bureau of Pathology was founded in May 1992.
• Its program focused on analyzing reproductive losses and perinatal mortality.
• Key principles included mass placental investigation and urgent diagnostics.

Purpose:

• To investigate the causes of early and late abortions.
• To assess fetal congenital anomalies and placental insufficiency.
• To determine the pathogenetic basis of intrauterine fetal demise and neonatal pathology.

Summary:

• Mass investigation of placentas revealed a primary pathogenetic role of ascending infections.
• Opportunistic pathogenic microflora drives inflammatory responses in the mother-placenta-fetus system.
• This contributes significantly to perinatal mortality.

Impact:

• Improved understanding of the etiology of perinatal mortality.
• Enhanced diagnostic capabilities for fetal development and placental health.
• Informed clinical practice and physician knowledge in placentology.