Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melanoma development from subcellular fractions.

H S Goldsmith, L Stettiner

    Surgery, Gynecology & Obstetrics
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cavity Cooling Using Ultrafast Electrons.

    Physical review letters·2025
    Same author

    Editorial: Omental transposition for cerebral revascularization.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Angiogenic capacity of human omental stem cells.

    Neurological research·2005
    Same author

    Fecal control following pyloric valve transposition after abdominoperineal resection.

    Techniques in coloproctology·2003
    Same author

    Role of the omentum in the treatment of Alzheimer's disease.

    Neurological research·2001
    Same author

    Omental transposition for cerebral infarction: a 13-year follow-up study.

    Surgical neurology·1999
    Same journal

    THE USE OF COMBINED PRESERVATION TECHNIQUES FOR EXTENDED STORAGE OF ORTHOTOPIC LIVER HOMOGRAFTS.

    Surgery, gynecology & obstetrics·2010
    Same journal

    The Role of Electrical Pacemakers in the Treatment of Unexpected Cardiac Arrest.

    Surgery, gynecology & obstetrics·2010
    Same journal

    Colonic and proctoscopic diseases.

    Surgery, gynecology & obstetrics·2010
    Same journal

    A summary of the surgical aspects of certain sulfonamides and antibiotic agents.

    Surgery, gynecology & obstetrics·2010
    Same journal

    Penetrating cranial wounds; a summary of methods used in management; collective review.

    Surgery, gynecology & obstetrics·2010
    Same journal

    The use of compression in the treatment of injuries.

    Surgery, gynecology & obstetrics·2010
    See all related articles

    Melanoma can be induced by subcellular particles from disrupted amelanotic melanoma cells. This suggests oncogenic information transfer may not require intact cells or viral agents.

    Area of Science:

    • Oncology
    • Cell Biology
    • Cancer Research

    Background:

    • Amelanotic melanoma is a challenging subtype of melanoma.
    • Understanding melanoma oncogenesis is crucial for developing new therapies.

    Purpose of the Study:

    • To investigate the oncogenic potential of subcellular particles from amelanotic melanoma cells.
    • To determine if melanoma can be induced by non-intact melanoma components.

    Main Methods:

    • Amelanotic melanoma cells (RPMI-1846) were disrupted using sonic energy.
    • Liberated subcellular particles were injected into syngeneic and nonsyngeneic hamsters.
    • Electron microscopy and phase microscopy were used to analyze injected material.

    Main Results:

    Related Experiment Videos

    • A significant number of injected hamsters developed melanoma.
    • This indicates that subcellular melanoma particles possess oncogenic potential.
    • Analysis confirmed the absence of intact melanoma cells in the injected material.

    Conclusions:

    • Melanoma can be induced by subcellular components released from disrupted melanoma cells.
    • Oncogenic information transfer may occur independently of intact cells or viral agents.
    • This finding opens new avenues for understanding melanoma metastasis and treatment.