Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predictive value of pulmonary function tests before marrow transplantation.

S W Crawford1, L Fisher

  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle.

Chest
|May 1, 1992
PubMed
Summary

Pulmonary function tests (PFTs) like diffusion capacity of the lungs for carbon monoxide (Dcosb) and alveolar-arterial oxygen gradient (P(A-a)O2) predict mortality risk after marrow transplant. Abnormal pre-transplant PFTs indicate increased risk but should not exclude patients from this life-saving procedure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Women's engagement with community perinatal mental health services: a realist evaluation.

BMC psychiatry·2024
Same author

Postoperative mortality and complications in patients with and without pre-operative SARS-CoV-2 infection: a service evaluation of 24 million linked records using OpenSAFELY.

Anaesthesia·2023
Same author

A new perspective on diabetes distress using the type 2 diabetes distress assessment system (T2-DDAS): Prevalence and change over time.

Journal of diabetes and its complications·2022
Same author

"Hyperglycemia aversiveness": Investigating an overlooked problem among adults with type 1 diabetes.

Journal of diabetes and its complications·2021
Same author

Synergy between callous-unemotional traits and aggression in preschool children: Cross-informant and cross-cultural replication in the UK Wirral Child Health and Development Study, and the Colombian La Sabana Parent-Child Study.

Development and psychopathology·2021
Same author

Worries and concerns about hypoglycemia in adults with type 1 diabetes: An examination of the reliability and validity of the Hypoglycemic Attitudes and Behavior Scale (HABS).

Journal of diabetes and its complications·2020

Area of Science:

  • Hematology
  • Pulmonology
  • Oncology

Background:

  • Marrow transplantation is a critical treatment for various malignancies.
  • Assessing pre-transplant risk factors is crucial for patient outcomes.
  • Pulmonary function tests (PFTs) evaluate lung health before transplantation.

Purpose of the Study:

  • To determine the association between pre-transplant pulmonary function tests (PFTs) and post-transplant mortality.
  • To identify specific PFT parameters that predict mortality risk in marrow transplant recipients.

Main Methods:

  • Retrospective case-series review of 1297 patients undergoing first marrow transplant for malignancy (1986-1990).
  • Analysis included PFTs: FEV1/FVC, P(A-a)O2 gradient, TLC, and Dcosb.
  • Proportional hazards regression models assessed PFTs' predictive value beyond other covariates (age, diagnosis, relapse, HLA status).

Related Experiment Videos

Main Results:

  • Overall 6-month mortality was 44%; respiratory failure occurred in 23% of patients.
  • Abnormalities in TLC, Dcosb, and P(A-a)O2 were associated with increased mortality in univariate analysis.
  • Diffusion capacity of the lungs for carbon monoxide (Dcosb) and alveolar-arterial oxygen gradient (P(A-a)O2) were independent risk factors for death.

Conclusions:

  • Pre-transplant decreased Dcosb and increased P(A-a)O2 significantly increase mortality risk after marrow transplant.
  • Abnormal PFTs indicate higher risk but are less significant than relapse status or HLA nonidentity.
  • PFTs should guide risk assessment but not serve as absolute exclusion criteria for marrow transplantation.