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Genistein reverses changes of the proteome induced by oxidized-LDL in EA.hy 926 human endothelial cells
Dagmar Fuchs1, Petra Erhard, Rufus Turner
1Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D-85350 Freising, Germany.
Abstract:
Endothelial cells are primary targets for pro-atherosclerotic stressors such as oxidized LDL (ox-LDL). The isoflavone genistein, on the other hand, is suggested to prevent a variety of processes underlying atherosclerosis and cardiovascular diseases. By analyzing the proteome of EA.hy 926 endothelial cells, here we show, that genistein reverses the ox-LDL-induced changes of the steady-state levels of several proteins involved in atherosclerosis. These alterations caused by genistein are functionally linked to the inhibition of ox-LDL induced apoptosis.

