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Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection
D N Amin1, K Sperber, L K Brown
1Division of Pulmonary and Critical Care Medicine, Mount Sinai Medical Center, New York.
Chest
|May 1, 1992
Abstract:
We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were active in the patient with asymptomatic HIV infection. Both patients had granulomatous reactions to Kveim antigen, and one had such a reaction following an AIDS-defining infection. These findings suggest that non-T-cell mechanisms may be involved in granuloma formation in sarcoidosis.