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Related Experiment Videos

Transient neonatal hyperthyrotropinaemia.

T T Lao1, C Y Li, N S Panesar

  • 1Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Shatin, Hong Kong.

Early Human Development
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Elevated umbilical cord plasma thyrotropin (TSH) in newborns is often transient, not indicative of congenital hypothyroidism. This finding suggests TSH elevation may signal delivery stress in healthy infants.

Area of Science:

  • Neonatal endocrinology
  • Perinatal stress response

Background:

  • Elevated umbilical venous plasma thyrotropin (TSH) is a screening concern for congenital hypothyroidism.
  • Distinguishing transient TSH elevation from true hypothyroidism is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To investigate the causes of elevated umbilical cord plasma TSH in newborns.
  • To determine the correlation between delivery complications and transient TSH elevation.

Main Methods:

  • Analysis of 48 newborns with elevated TSH.
  • Comparison with matched control groups.
  • Assessment of delivery parameters including mode of delivery, labor duration, and cord encirclement.

Main Results:

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  • Only 4% of newborns with elevated TSH had congenital hypothyroidism; 96% showed transient elevation.
  • Transient TSH elevation was associated with vaginal delivery, prolonged second stage of labor, nuchal cord, and female sex.
  • No differences were observed in antenatal complications, gestational age, birth weight, or birth asphyxia.

    • Conclusions:

    • Elevated umbilical cord plasma TSH in healthy, appropriate- or large-for-gestational age newborns often indicates a stress response to complicated delivery.
    • Transient TSH elevation is common and typically not associated with congenital hypothyroidism.