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Atopy patch test--reproducibility and elicitation of itch in different application sites
Stephanie Weissenbacher1, Theresa Bacon, Darren Targett
1Department of Dermatology and Allergy, Biederstein Technical University, D-80802 Munich, Germany.
Acta Dermato-Venereologica
|April 13, 2005
Summary
The atopy patch test (APT) is reproducible and can induce itch. Applying allergens on the back may improve reaction detection, but itch can occur regardless of the application site.
Area of Science:
- Dermatology
- Allergology
- Clinical Immunology
Background:
- Atopic eczema is a common inflammatory skin condition.
- The atopy patch test (APT) is used to identify specific allergens contributing to atopic eczema.
- Reproducibility and optimal application sites for APT require further investigation.
Purpose of the Study:
- To assess the reproducibility of atopy patch test (APT) reactions.
- To evaluate the quality and quantity of itch induced by APT.
- To compare the efficacy of APT on different application sites (forearms vs. back).
Main Methods:
- 16 patients with atopic eczema and positive APT history were included.
- Allergens were applied to both forearms and the back simultaneously.
- Itch intensity and quality were measured using visual analogue scale and Eppendorf itch questionnaire.
Main Results:
- APT reactions were highly reproducible (94% positive).
- Pruritus was reported by 88% of patients, with no significant difference in intensity or quality between sites.
- Positive reactions and peak scores were higher on the back compared to the forearms.
Conclusions:
- The atopy patch test (APT) is a reproducible diagnostic tool for atopic eczema.
- Application of allergens on the back is preferred for improved reaction detection.
- APT can induce atopic itch, irrespective of the allergen application site.