Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Incomitance in monkeys with strabismus.

Vallabh E Das1, Lai Ngor Fu, Michael J Mustari

  • 1Division of Visual Science, Yerkes National Primate Research Center, and Department of Neurology, Emory University, Atlanta, GA 30322, USA. vdas@rmy.emory.edu

Strabismus
|April 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates.

Investigative ophthalmology & visual science·2026
Same author

Relationship between form-deprivation myopia and amblyopic deficit.

Vision research·2026
Same author

Neural Innervation of Cyclovertical Extraocular Muscles During Asymmetric Vertical Vergence.

Investigative ophthalmology & visual science·2026
Same author

Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.

Brain : a journal of neurology·2025
Same author

Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters.

Nature communications·2024
Same author

An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models.

Nature communications·2024
Same journal

Motor and sensory outcomes after botulinum toxin A injection versus unilateral medial rectus recession in small-to-moderate angle esotropia.

Strabismus·2026
Same journal

Bimedial rectus recession versus botulinum toxin injection for the treatment of infantile esotropia.

Strabismus·2026
Same journal

Worsening abducens paresis and chronic orbital venous congestion after carotid-cavernous fistula embolization: long-term motility outcomes.

Strabismus·2026
Same journal

Strabismus following Endonasal sinus surgery: a 10-year retrospective analysis of clinical profile and outcomes.

Strabismus·2026
Same journal

Correction.

Strabismus·2026
Same journal

Surgical management of iatrogenic medial rectus transection following functional endoscopic sinus surgery: a report of two cases.

Strabismus·2026
See all related articles

Rearing monkeys with restricted vision causes strabismus, including A/V patterns and dissociated vertical deviation (DVD). This creates a valuable model for studying human incomitant strabismus and DVD mechanisms.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Animal Models

Background:

  • Restricted visual environments in early life can lead to significant ocular misalignment (strabismus) in rhesus monkeys.
  • Understanding the mechanisms behind strabismus, particularly A/V patterns and dissociated vertical deviation (DVD), is crucial for treating human patients.

Purpose of the Study:

  • To characterize A/V patterns and DVD in rhesus monkeys with visually induced strabismus.
  • To establish these animals as a suitable model for investigating the causes of incomitant strabismus and DVD in humans.

Main Methods:

  • Binocular eye movements were recorded using search coils during fixation, smooth pursuit, and saccades.
  • Subjects included one monkey with esotropia, three with exotropia, and one normal control.

Related Experiment Videos

Main Results:

  • Monkeys with visual deprivation exhibited both horizontal and vertical misalignments.
  • 'A' patterns were observed in exotropic monkeys, and a 'V' pattern in the esotropic monkey.
  • Vertical misalignment consistent with DVD was noted, with the non-viewing eye positioned higher.

Conclusions:

  • Visual deprivation in monkeys induces A/V patterns and DVD, mirroring human strabismus types.
  • The underlying cause may involve central (neural innervation) or peripheral (muscle pulley) alterations.
  • These monkeys serve as a relevant model for studying the pathogenesis of pattern strabismus and DVD.