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Updated: Aug 18, 2026

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
[Corneal wound healing response following different modalities of refractive surgical procedures]
Marcelo Vieira Netto1, Renato Ambrósio, Maria Regina Chalita
1Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA. nettom@ccf.org
Abstract:
The corneal wound healing response following refractive procedures represents a subject of high relevance, due to its direct influence on the postoperative results. Technical modifications of current refractive procedures, like the automated flap creation with the femtosecond laser, LASEK, PRK with mitomycin C and Epi-LASIK have been proposed as alternatives to traditional LASIK and PRK. Several theoretical advantages have encouraged the diffusion of these new techniques; however, a better understanding of the corneal wound healing response following these procedures is required. The present text proposes a review of the corneal wound healing characteristics following different modalities of refractive surgical procedures.
